Image : Spinal cord neurons are labeled by GFP (in white) in 1 day old Tg(elavl3:GCaMP) embryo. Motoneurons are pseudocolored in blue and an interneuron in red.
Development of the spinal pre-motor circuit
Do the activity of motoneurons regulate the wiring of the interneuron-motoneuron circuit ?
We have recently shown that interneurons express a variety of nicotinic acetylcholine receptors, while motoneurons express genes that synthesize and release acetylcholine (Rima et al., 2020). We are currently investigating whether the acetylcholine released from motoneurons influence the activity, growth and synaptogenesis of interneurons in the embryonic spinal cord.