Decoding the neural architecture of behavior.
A chemosensory receptor does not switch from “on” to “off” when its ligand disappears. The decisive control point is usually the receptor’s phosphorylation state while the ligand is still present. Kinases add…
When photons strike the retina, the signal travels first to V1, the primary visual cortex, where neurons respond to…
A zebrafish olfactory assay fails when the stimulus is treated as a simple liquid exchange. It is not. The experiment…
You're staring at your hundredth confocal stack of zebrafish hindbrain, and you can describe every cell in your network…
The zebrafish olfactory bulb is a small organ with a difficult job. Roughly the size of a pinhead, it packs…
Every fluorescent trace tells two stories. One is the signal you want: a glomerulus lighting up as an odorant binds its…
Okay, so picture this: you've spent three weeks prepping your EEG pipeline, you've got a clean signal from your Muse…
A single residue shift of about 6 Å separates one sensory GPCR at rest from one in full activation. That distance is…
You've got the data. Maybe you spent three months injecting the right construct, raising your larvae to 6 days…
A mechanical lesion in a three-day-old zebrafish larva closes within roughly forty-eight hours. Within several days…
Many mammalian olfactory receptors do not fail in a heterologous assay because their ligand is unknown or their…
You can have a beautiful transgenic line, a healthy clutch, and a perfectly aligned light path—and still get the wrong…
A science-art exhibit can close the baseline interest gap between STEM and non-STEM adults in a single visit. That…
A zebrafish behavior assay can produce thousands of frames in a single session, but raw video is not yet a measurement…
Your larval zebrafish are swimming, the stimulus streams look beautifully separated, and the tracking software is…
You have a spinal cord roughly 300 microns wide. It contains hundreds of interneuron subtypes making thousands of…
Neural data does not arrive in a form that music can immediately understand. An EEG trace is a changing voltage…
Your calcium movie looks clean until you ask the uncomfortable question: are those neural signals from the larva, or…
A single odorant molecule contacting an olfactory sensory neuron does not enter a clean relay. It enters a sequence of…
Neuronal migration is not a quiet relocation from one point in the brain to another. It is a sequence of decisions made…
A brain wave music project usually fails before the first note plays. The headset loses contact, the signal fills with…
A confocal stack can look perfect and still be analytically unusable. Fluorescent reporters are firing across the optic…
Detecting olfactory receptors outside the olfactory epithelium is less like finding a bright signal than like…
You're staring down the scope at a perfectly prepped stripe assay — alternating lanes of netrin-1 and BSA, your…
A 22% drop in salivary cortisol. A 30% reduction in interleukin-6. A 28% decline in TNF-alpha. These are not…
Brain data has a shape problem. The electrical chatter of neurons — the slow drift of cortical oscillations, the crisp…
You can have a beautiful zebrafish brain movie, a stable preparation, and a perfectly healthy-looking larva—and still…
A single bolus of capsaicin injected into deep craniofacial tissue drops the mechanical activation threshold of…
The habenulo-interpeduncular pathway is a compact tract with an unusually large interpretive burden. In zebrafish, the…
A light-sheet zebrafish brain protocol can fail before the microscope ever starts collecting data. The usual culprit is…
A larval zebrafish can discriminate between two chemical cues delivered 100 µm apart—across paired nasal cavities…
A range of 80 to 97 percent. That is the decline in insect populations represented by a prominent ecological…
During a fast volumetric calcium scan, a larval zebrafish twitches — a reflex adjustment, a momentary flex in a quiet…
You've pulled the fish out of the tank, you've pipetted what should be a perfect bolus of indicator into the naris…
You can record calcium activity across the entire larval brain. That part is solved. The harder problem is assigning…